We have discussed in detail hGH replacement therapy with both somatropin (hGH) and the hGH releasing peptides sermorelin, GHRP-6 and GHRP-2, comparing benefits and disadvantages of each. The table below provides a summary of this information comparing hGH and hGH releasing peptides.
hGH vs Peptides
|hGH (Somatropin)||hGH Stimulating Peptides (eg. Sermorelin, GHRP-6 & GHRP-2)|
|Effects on hGH Levels||Promotes unnatural hGH levels||Promotes natural release of hGH|
|Can suppress natural hGH production||Promotes natural hGH production|
| Effect on|
|Can negatively impact pituitary function||Supports healthy pituitary function|
|hGH levels drop when therapy is stopped||Promote hGH production for a period after therapy is stopped|
|Benefits||All the benefits of healthy hGH levels||The same benefits as hGH, without the risk|
|Safety||High risk of overdose||Very low (to no) risk of overdose|
|Risk of Tachyphylaxis||No risk of Tachyphylaxis|
|Associated with a range of side-effects||Minimal side-effects, less severe|
|Accessibility||Controlled substance, hard to access legally||Readily available through legal means|
|Cost||Higher cost ($1000+ per month)||Lower cost ($270+ per month)|
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Pituitary Gland – This gland is located at the base of the brain and is responsible for (amongst other functions) healthy secretion of human growth hormone (hGH).
Benefits – You can obtain the same benefits with hGH stimulating peptides (sermorelin and GHRP-2) as are achieved with hGH (somatropin) but you do so without the risks. These benefits include changes in body composition, bone strength, energy levels and exercise performance (to name a few).
Tachyphylaxis – this medical term describes a sudden decrease in response to a drug following its administration. The risk of tachyphylaxis when using hGH is due to the persistent elevated concentrations of hGH. In contrast, hGH stimulating peptides provide a natural release of hGH, thereby minimizing risk of tachyphylaxis.
Controlled Substance – hGH is a controlled substance which means that you can only legally obtain it with a prescription. The conditions for which hGH can be prescribed are heavily regulated by the FDA, the result being that only a small group of people diagnosed with those conditions can gain access to the drug. Like any drug, hGH can be sourced illegally but you not only risk being caught breaking the law, you also risk your health since there is no way to be assured of the quality of an illegally purchased product. In comparison, hGH stimulating peptides are commonly prescribed and legally purchased.
Side-effects of hGH – Known side-effects of hGH include carpal tunnel syndrome, abnormal bone and tissue growth, breast tissue enlargement (in men) heart problems and increased risk of diabetes. hGH has also been linked to cancer and can shut down the body’s natural hGH production. Sermorelin and other hGH stimulating peptides have much fewer and less severe side-effects such as headache, flushing, dizziness, hyperactivity and sleeplessness.