Peptides Vs HGH – Safety, Accessibility, Benefits & Cost Comparisons

June 16, 2024 //

In a society that wants to look younger, feel younger, live longer and basically defy the process of aging, it is not surprising that hGH therapy has become such a popular means of achieving these goals.

With the ever-increasing popularity of hGH therapy, there has been much debate about its reported benefits, safety and cost.

HGH stimulating peptides such as Sermorelin, GHRP-6 and GHRP-2 have also been offered up as a safer and more affordable option.

Lets compare each to determine which is better – HGH or peptides.

hGH vs Peptides

Effects on HGH Levels

HGH (Somatropin) – Promotes unnatural HGH levels and can suppress natural HGH production.

Peptides – Promote natural production and release of HGH

Effects on the Pituitary Gland

This gland is located at the base of the brain and is responsible for (amongst other functions) healthy secretion of human growth hormone (hGH).

HGH (Somatropin) – Can negatively impact pituitary function causing natural HGH levels to drop when therapy is stopped.

Peptides – Support healthy pituitary function and promote natural HGH production for a period after the therapy is stopped.

Health Benefits

You can obtain the same benefits with hGH stimulating peptides (sermorelin and GHRP-2) as are achieved with hGH (somatropin) but you do so without the risks.

These benefits include changes in body composition, improved bone strength, better joint health, anti-aging effects, boosted energy levels and exercise performance (to name a few).


HGH (Somatropin) – Has a high risk of overdose, side effects and Tachyphylaxis.

Tachyphylaxis describes a sudden decrease in response to a drug following its administration.

The risk of tachyphylaxis when using hGH is due to the persistent elevated concentrations of hGH.

In contrast, hGH stimulating peptides provide a natural release of hGH, thereby minimizing risk of tachyphylaxis.

Known side-effects of hGH include carpal tunnel syndrome, abnormal bone and tissue growth, breast tissue enlargement (in men) heart problems and increased risk of diabetes.

hGH has also been linked to cancer and can shut down the body’s natural hGH production.

Peptides – These have very low (to no) risk of overdose or Tachyphylaxis.

Sermorelin and other hGH stimulating peptides have much fewer and less severe side-effects such as headache, flushing, dizziness, hyperactivity and sleeplessness.


HGH (Somatropin) – Is a Controlled Substance and therefore hard to access legally.

A Controlled Substance is one that you can only legally obtain it with a prescription. The conditions for which hGH can be prescribed are heavily regulated by the FDA, the result being that only a small group of people diagnosed with those conditions can gain access to the drug.

Like any drug, hGH can be sourced illegally but you not only risk being caught breaking the law, you also risk your health since there is no way to be assured of the quality of an illegally purchased product.

Peptides – Are not a controlled substance so are commonly prescribed and legally purchased.


HGH (Somatropin) – Has a high cost of over $1000+ per month

Peptides – Have a lower cost of $250+ per month

Here is a great infographic that summarizes all of this information:


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